Mobile Edge Computing （MEC） can reduce the energy consumption of mobile devices and the delay of users’ acquisition to services by deploying resources in users’ neighborhood； however， most relevant caching studies ignore the regional differences of the services requested by users. A cache cooperation strategy for maximizing revenue was proposed by considering the features of requested content in different regions and the dynamic characteristic of content. Firstly， considering the regional features of user preferences， the base stations were partitioned into several collaborative domains， and the base stations in each collaboration domain was able to serve users with the same preferences. Then， the content popularity in each region was predicted by the Auto?Regressive Integrated Moving Average （ARIMA） model and the similarity of the content. Finally， the cache cooperation problem was transformed into a revenue maximization problem， and the greedy algorithm was used to solve the content placement and replacement problems according to the revenue obtained by content storage. Simulation results showed that compared with the Grouping?based and Hierarchical Collaborative Caching （GHCC） algorithm based on MEC， the proposed algorithm improved the cache hit rate by 28% with lower average transmission delay. It can be seen that the proposed algorithm can effectively improve the cache hit rate and reduce the average transmission delay at the same time.